The mGluR5 Antagonist Fenobam Induces Analgesic Conditioned Place Preference in Mice with Spared Nerve Injury
Identifieur interne : 000D01 ( Main/Exploration ); précédent : 000D00; suivant : 000D02The mGluR5 Antagonist Fenobam Induces Analgesic Conditioned Place Preference in Mice with Spared Nerve Injury
Auteurs : Neil C. Lax ; David C. George ; Christopher Ignatz ; Benedict J. KolberSource :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- Analgésiques (pharmacologie), Animaux, Antagonistes des acides aminés excitateurs (pharmacologie), Conditionnement classique (), Femelle, Imidazoles (pharmacologie), Lésions des nerfs périphériques (physiopathologie), Morphine (pharmacologie), Mâle, Pyridines (pharmacologie), Récepteur-5 métabotropique du glutamate (antagonistes et inhibiteurs), Souris, Souris de lignée C57BL.
- MESH :
- antagonistes et inhibiteurs : Récepteur-5 métabotropique du glutamate.
- pharmacologie : Analgésiques, Antagonistes des acides aminés excitateurs, Imidazoles, Morphine, Pyridines.
- physiopathologie : Lésions des nerfs périphériques.
- Animaux, Conditionnement classique, Femelle, Mâle, Souris, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Analgesics (pharmacology), Animals, Conditioning, Classical (drug effects), Excitatory Amino Acid Antagonists (pharmacology), Female, Imidazoles (pharmacology), Male, Mice, Mice, Inbred C57BL, Morphine (pharmacology), Peripheral Nerve Injuries (physiopathology), Pyridines (pharmacology), Receptor, Metabotropic Glutamate 5 (antagonists & inhibitors).
- MESH :
- chemical , antagonists & inhibitors : Receptor, Metabotropic Glutamate 5.
- chemical , pharmacology : Analgesics, Excitatory Amino Acid Antagonists, Imidazoles, Morphine, Pyridines.
- drug effects : Conditioning, Classical.
- physiopathology : Peripheral Nerve Injuries.
- Animals, Female, Male, Mice, Mice, Inbred C57BL.
Abstract
Antagonists of metabotropic glutamate receptors (mGluRs) have the potential to act as analgesic drugs that may help alleviate chronic pain. This study was done to look at the possible rewarding properties of the mGluR5 antagonist, fenobam, in a cognitive assay. Analgesic conditioned place preference (aCPP) was used to examine the effects of fenobam (30 mg/kg) and the prototypical mGluR5 antagonist, MPEP, and these effects were compared to those of a drug with known analgesic properties, morphine (10 mg/kg). In each experiment, one group of mice received spared nerve injury (SNI) surgery to model chronic pain; the other group received a control sham surgery. Both fenobam and MPEP induced preference in the SNI mice, such that SNI mice spent significantly more time in the mGluR5 antagonist-paired chamber compared to a vehicle-paired chamber. No such preference developed for sham mice. Morphine induced preference in male and female mice in both the SNI and sham groups. The results showed that fenobam and MPEP likely reduced on-going distress in the SNI mice, causing them to prefer the chamber paired with the drug compared to the vehicle-paired chamber. Since sham animals did not prefer the drug-paired chamber, these data demonstrate that mGluR5 antagonism is non-rewarding in the absence of pain-like injury.
Url:
DOI: 10.1371/journal.pone.0103524
PubMed: 25061818
PubMed Central: 4111598
Affiliations:
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Le document en format XML
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Lax</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="George, David C" sort="George, David C" uniqKey="George D" first="David C." last="George">David C. George</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ignatz, Christopher" sort="Ignatz, Christopher" uniqKey="Ignatz C" first="Christopher" last="Ignatz">Christopher Ignatz</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kolber, Benedict J" sort="Kolber, Benedict J" uniqKey="Kolber B" first="Benedict J." last="Kolber">Benedict J. Kolber</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analgesics (pharmacology)</term><term>Animals</term><term>Conditioning, Classical (drug effects)</term><term>Excitatory Amino Acid Antagonists (pharmacology)</term><term>Female</term><term>Imidazoles (pharmacology)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Morphine (pharmacology)</term><term>Peripheral Nerve Injuries (physiopathology)</term><term>Pyridines (pharmacology)</term><term>Receptor, Metabotropic Glutamate 5 (antagonists & inhibitors)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analgésiques (pharmacologie)</term><term>Animaux</term><term>Antagonistes des acides aminés excitateurs (pharmacologie)</term><term>Conditionnement classique ()</term><term>Femelle</term><term>Imidazoles (pharmacologie)</term><term>Lésions des nerfs périphériques (physiopathologie)</term><term>Morphine (pharmacologie)</term><term>Mâle</term><term>Pyridines (pharmacologie)</term><term>Récepteur-5 métabotropique du glutamate (antagonistes et inhibiteurs)</term><term>Souris</term><term>Souris de lignée C57BL</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Receptor, Metabotropic Glutamate 5</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Analgesics</term><term>Excitatory Amino Acid Antagonists</term><term>Imidazoles</term><term>Morphine</term><term>Pyridines</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Récepteur-5 métabotropique du glutamate</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Conditioning, Classical</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Analgésiques</term><term>Antagonistes des acides aminés excitateurs</term><term>Imidazoles</term><term>Morphine</term><term>Pyridines</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lésions des nerfs périphériques</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Peripheral Nerve Injuries</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Conditionnement classique</term><term>Femelle</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Antagonists of metabotropic glutamate receptors (mGluRs) have the potential to act as analgesic drugs that may help alleviate chronic pain. This study was done to look at the possible rewarding properties of the mGluR5 antagonist, fenobam, in a cognitive assay. Analgesic conditioned place preference (aCPP) was used to examine the effects of fenobam (30 mg/kg) and the prototypical mGluR5 antagonist, MPEP, and these effects were compared to those of a drug with known analgesic properties, morphine (10 mg/kg). In each experiment, one group of mice received spared nerve injury (SNI) surgery to model chronic pain; the other group received a control sham surgery. Both fenobam and MPEP induced preference in the SNI mice, such that SNI mice spent significantly more time in the mGluR5 antagonist-paired chamber compared to a vehicle-paired chamber. No such preference developed for sham mice. Morphine induced preference in male and female mice in both the SNI and sham groups. The results showed that fenobam and MPEP likely reduced on-going distress in the SNI mice, causing them to prefer the chamber paired with the drug compared to the vehicle-paired chamber. Since sham animals did not prefer the drug-paired chamber, these data demonstrate that mGluR5 antagonism is non-rewarding in the absence of pain-like injury.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ingham, Jm" uniqKey="Ingham J">JM Ingham</name></author><author><name sortKey="Portenoy, Rk" uniqKey="Portenoy R">RK Portenoy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ng, Sc" uniqKey="Ng S">SC Ng</name></author><author><name sortKey="Chan, Fkl" uniqKey="Chan F">FKL Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benyamin, R" uniqKey="Benyamin R">R Benyamin</name></author><author><name sortKey="Trescot, Am" uniqKey="Trescot A">AM Trescot</name></author><author><name sortKey="Datta, S" uniqKey="Datta S">S Datta</name></author><author><name sortKey="Buenaventura, R" uniqKey="Buenaventura R">R 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Huang</name></author><author><name sortKey="Banisadr, G" uniqKey="Banisadr G">G Banisadr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goncalves, L" uniqKey="Goncalves L">L Gonçalves</name></author><author><name sortKey="Silva, R" uniqKey="Silva R">R Silva</name></author><author><name sortKey="Pinto Ribeiro, F" uniqKey="Pinto Ribeiro F">F Pinto-Ribeiro</name></author><author><name sortKey="Pego, Jm" uniqKey="Pego J">JM Pêgo</name></author><author><name sortKey="Bessa, Jm" uniqKey="Bessa J">JM Bessa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reid, Ld" uniqKey="Reid L">LD Reid</name></author><author><name sortKey="Marglin, Sh" uniqKey="Marglin S">SH Marglin</name></author><author><name sortKey="Mattie, Me" uniqKey="Mattie M">ME Mattie</name></author><author><name sortKey="Hubbell, Cl" uniqKey="Hubbell C">CL Hubbell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vindenes, V" uniqKey="Vindenes V">V Vindenes</name></author><author><name sortKey="Handal, M" uniqKey="Handal M">M Handal</name></author><author><name sortKey="Ripel, " uniqKey="Ripel ">Å Ripel</name></author><author><name sortKey="Boix, F" uniqKey="Boix F">F Boix</name></author><author><name sortKey="M Rland, J" uniqKey="M Rland J">J Mørland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohammed, W" uniqKey="Mohammed W">W Mohammed</name></author><author><name sortKey="Alhaddad, H" uniqKey="Alhaddad H">H Alhaddad</name></author><author><name sortKey="Marie, N" uniqKey="Marie N">N Marie</name></author><author><name sortKey="Tardy, F" uniqKey="Tardy F">F Tardy</name></author><author><name sortKey="Lamballais, F" uniqKey="Lamballais F">F Lamballais</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="George, David C" sort="George, David C" uniqKey="George D" first="David C." last="George">David C. George</name><name sortKey="Ignatz, Christopher" sort="Ignatz, Christopher" uniqKey="Ignatz C" first="Christopher" last="Ignatz">Christopher Ignatz</name><name sortKey="Kolber, Benedict J" sort="Kolber, Benedict J" uniqKey="Kolber B" first="Benedict J." last="Kolber">Benedict J. Kolber</name><name sortKey="Lax, Neil C" sort="Lax, Neil C" uniqKey="Lax N" first="Neil C." last="Lax">Neil C. Lax</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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